Mycobacterium Tuberculosis Nucleic Acid thiab Rifampicin Resistance

Mycobacterium tuberculosis, luv luv li Tubercle bacillus, TB, yog cov kab mob pathogenic uas ua rau tuberculosis.Tam sim no, cov tshuaj tiv thaiv kab mob ua ntej siv feem ntau suav nrog isoniazid, rifampicin thiab hexambutol, thiab lwm yam. Cov tshuaj tiv thaiv kab mob thib ob muaj xws li fluoroquinolones, amikacin thiab kanamycin, thiab lwm yam. Cov tshuaj tsim tshiab yog linezolid, bedaquiline thiab delamani, thiab lwm yam. .Txawm li cas los xij, vim yog siv cov tshuaj tiv thaiv kab mob tsis raug thiab cov yam ntxwv ntawm lub cell phab ntsa qauv ntawm mycobacterium tuberculosis, mycobacterium tuberculosis tsim cov tshuaj tiv thaiv rau cov tshuaj tiv thaiv tuberculosis, uas ua rau muaj teeb meem loj rau kev tiv thaiv thiab kho tuberculosis.

Rifampicin tau siv dav hauv kev kho mob ntsws ntsws tuberculosis txij thaum xyoo 1970s, thiab muaj txiaj ntsig zoo.Nws tau yog thawj qhov kev xaiv los ua kom luv luv ntawm cov kws khomob ntawm cov neeg mob ntsws tuberculosis.Rifampicin tsis kam yog feem ntau tshwm sim los ntawm kev hloov pauv ntawm rpoB noob.Txawm hais tias cov tshuaj tiv thaiv kab mob tshiab tau tawm los tas li, thiab kev kho mob ntawm cov neeg mob ntsws ntsws ntsws kuj tseem txhim kho, tseem muaj cov txheeb ze tsis muaj cov tshuaj tiv thaiv kab mob, thiab qhov tshwm sim ntawm kev siv tshuaj irrational hauv kev kho mob kuj yog siab.Pom tseeb, Mycobacterium tuberculosis nyob rau hauv cov neeg mob pulmonary tuberculosis tsis tuaj yeem tua tag nrho raws sijhawm, uas nws thiaj li ua rau muaj kev sib txawv ntawm cov tshuaj tiv thaiv hauv tus neeg mob lub cev, ua rau lub sijhawm ntev ntawm tus kab mob, thiab ua rau muaj kev pheej hmoo ntawm kev tuag ntawm tus neeg mob.