Tib neeg CYP2C9 thiab VKORC1 Gene Polymorphism
Khoom npe
HWTS-GE014A-Human CYP2C9 thiab VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)
Daim ntawv pov thawj
CE
Kab mob sib kis
Warfarin yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj uas feem ntau siv hauv kev kho mob tam sim no, uas yog tsim los rau kev tiv thaiv thiab kho cov kab mob thromboembolic.Txawm li cas los xij, warfarin muaj qhov kev kho mob tsawg thiab sib txawv ntawm ntau haiv neeg thiab tib neeg.Kev txheeb xyuas tau qhia tias qhov sib txawv ntawm cov koob tshuaj ruaj khov hauv cov tib neeg sib txawv tuaj yeem muaj ntau dua 20 npaug.Qhov tshwm sim tsis zoo los ntshav tshwm sim hauv 15.2% ntawm cov neeg mob noj tshuaj warfarin txhua xyoo, ntawm 3.5% tsim los ntshav tuag.Cov kev tshawb fawb Pharmacogenomic tau pom tias genetic polymorphism ntawm lub hom phiaj enzyme VKORC1 thiab metabolic enzyme CYP2C9 ntawm warfarin yog ib qho tseem ceeb cuam tshuam rau qhov sib txawv ntawm koob tshuaj warfarin.Warfarin yog ib qho tshwj xeeb inhibitor ntawm vitamin K epoxide reductase (VKORC1), thiab yog li inhibits clotting factor synthesis uas muaj vitamin K thiab muab anticoagulation.Ntau cov kev tshawb fawb tau qhia tias cov noob polymorphism ntawm VKORC1 tus txhawb nqa yog qhov tseem ceeb tshaj plaws cuam tshuam rau haiv neeg thiab tus kheej sib txawv ntawm qhov xav tau ntawm koob tshuaj warfarin.Warfarin yog metabolized los ntawm CYP2C9, thiab nws cov mutants qeeb qeeb metabolism ntawm warfarin.Cov tib neeg uas siv warfarin muaj kev pheej hmoo siab dua (ob zaug mus rau peb zaug ntau dua) los ntshav thaum ntxov ntawm kev siv.
Channel
| FAM | VKORC1 (-1639G>A) |
| CY 5 | CYP2C9*3 |
| VIC/HEX | IC |
Technical Parameters
| Cia | Ua kua: ≤-18 ℃ |
| Txee lub neej | 12 hli |
| Hom Qauv | Fresh EDTA anticoagulated ntshav |
| CV | ≤ 5.0% |
| LoD | 1.0 ng / μL |
| Qhov tshwj xeeb | Tsis muaj kev sib cuam tshuam nrog lwm cov kab ke sib luag ntawm tib neeg genome (tib neeg CYP2C19 noob, tib neeg RPN2 noob);Kev hloov pauv ntawm CYP2C9 * 13 thiab VKORC1 (3730G> A) sab nraum qhov kev tshawb pom ntawm cov khoom siv no |
| Cov cuab yeej siv tau | Siv Biosystems 7500 Real-Time PCR Systems Siv Biosystems 7500 Fast Real-Time PCR Systems QuantStudio®5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler® 480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
Ua hauj lwm Flow
Pom zoo extraction reagent: Macro & Micro-Test Viral DNA / RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) thiab Macro & Micro-Test Automatic Nucleic Acid Extractor (HWTS- 3006).
