Tib neeg CYP2C19 Gene Polymorphism

CYP2C19 yog ib qho tseem ceeb ntawm cov tshuaj metabolizing enzymes hauv tsev neeg CYP450.Ntau yam endogenous substrates thiab txog 2% ntawm cov tshuaj kho mob yog metabolized los ntawm CYP2C19, xws li cov metabolism hauv antiplatelet aggregation inhibitors (xws li clopidogrel), proton twj tso kua mis inhibitors (omeprazole), anticonvulsants, thiab lwm yam. yam tshuaj.Cov kev hloov pauv no ntawm * 2 (rs4244285) thiab * 3 (rs4986893) ua rau poob ntawm cov enzyme kev ua los ntawm CYP2C19 noob thiab tsis muaj zog ntawm cov metabolism hauv substrate, thiab nce ntshav concentration, thiaj li ua rau muaj kev phiv tshuaj cuam tshuam nrog ntshav concentration.* 17 (rs12248560) tuaj yeem ua kom cov enzyme kev ua tau zoo los ntawm CYP2C19 noob, tsim cov metabolites nquag, thiab txhim kho cov platelet aggregation inhibition thiab ua rau muaj kev pheej hmoo los ntshav.Rau cov neeg uas muaj cov metabolism hauv qeeb qeeb, noj cov tshuaj ib txwm ua rau lub sijhawm ntev yuav ua rau muaj kev phom sij loj thiab cov kev mob tshwm sim: feem ntau ntawm daim siab puas, hematopoietic system puas, hauv nruab nrab paj hlwb puas, thiab lwm yam, uas tuaj yeem ua rau tuag taus.Raws li tus neeg sib txawv ntawm cov tshuaj metabolism, nws feem ntau muab faib ua plaub phenotypes, uas yog ultra-ceev metabolism (UM, * 17 / * 17, * 1 / * 17), ceev metabolism (RM, * 1 / * 1). ), intermediate metabolism (IM, *1/*2, *1/*3), qeeb metabolism (PM, *2/*2, *2/*3, *3/*3).