Tib neeg BCR-ABL Fusion Gene Mutation
Khoom npe
HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Kab mob sib kis
Chronic myelogenousleukemia (CML) yog ib hom kab mob qog nqaij hlav ntawm hematopoietic qia hlwb.Ntau tshaj 95% ntawm CML cov neeg mob nqa Philadelphia chromosome (Ph) hauv lawv cov qe ntshav.Predominant pathogenesis ntawm CML yog raws li hauv qab no: BCR-ABL fusion noob yog tsim los ntawm kev hloov pauv ntawm abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ntawm caj npab ntev ntawm chromosome 9 (9q34) thiab thaj tsam breakpoint pawg ( BCR) noob ntawm caj npab ntev ntawm chromosome 22 (22q11);fusion protein encoded los ntawm cov noob no muaj tyrosine kinase (TK) kev ua, thiab ua kom nws txoj hauv kev qis qis (xws li RAS, PI3K, thiab JAK/STAT) los txhawb kev faib cell thiab inhibit cell apoptosis, ua rau cov hlwb proliferate malignantly, thiab yog li ua rau. qhov tshwm sim ntawm CML.BCR-ABL yog ib qho tseem ceeb ntawm kev kuaj mob ntawm CML.Qhov kev hloov pauv hloov ntawm nws cov ntawv sau tseg yog qhov qhia tau zoo rau kev txiav txim siab ntawm leukemia thiab tuaj yeem siv los kwv yees qhov rov tshwm sim ntawm leukemia tom qab kho.
Channel
| FAM | BCR-ABL fusion noob |
| VIC/HEX | Internal Control |
Technical Parameters
| Cia | Ua kua: ≤-18 ℃ Hauv tsaus |
| Txee lub neej | Kua: 9 lub hlis |
| Hom Qauv | Cov kab mob qog nqaij hlav |
| LoD | 1000 Daim / mL |
| Qhov tshwj xeeb
| Tsis muaj kev sib cuam tshuam nrog lwm cov noob fusion TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, thiab PML-RARa |
| Cov cuab yeej siv tau | Siv Biosystems 7500 Real-Time PCR Systems Siv Biosystems 7500 Fast Real-Time PCR Systems QuantStudio® 5 Real-Time PCR Systems SLAN-96P Real-Time PCR Systems LightCycler® 480 Real-Time PCR system LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Real-Time Quantitative Thermal Cycler BioRad CFX96 Real-Time PCR System BioRad CFX Opus 96 Real-Time PCR System |
